Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19
نویسندگان
چکیده
منابع مشابه
Letter: Covid-19, and vitamin D
Vitamin D is an immune modulator hormone with an anti-inflammatory effect. In this study the potential association between vitamin D and risk of Covid-19 disease were examined. Data of worldwide mortality rate of Covid-19 pandemic according to geographical distribution in 108 countries were analyzed. The results shows Covid-19 outbreaks and particularly mortality exhibit a decreasing North-Sout...
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Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...
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Vitamin D comprises a group of fat-soluble pro-hormones, obtained from sun exposure, food, and supplements, and it must undergo two hydroxylation reactions to be activated in the body. Several studies have shown the role of vitamin D in mineral metabolism regulation, especially calcium, phosphorus, and bone metabolism. Some factors such as inadequate vitamin intake and liver or kidney disorders...
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Vitamin D is a fat soluble vitamin with a well-known general metabolism and actions in bone structure and immune system regulation. Vitamin D exhibits direct antimicrobial activities against a spectrum of microbes, including Gram-positive and Gram-negative bacteria, enveloped and non-enveloped viruses, as well as fungi. An observational study showed that concentrations of 38 ng/ml or more were ...
متن کاملVitamin D Binding Protein and Vitamin D Levels
1 Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 2 Clinical Research, Diabetes and Endocrinology, Merck Research Laboratories, 126 East Lincoln Avenue, RY34B-148, Rahway, NJ 07065-0900, USA 3Department of Nutritional Science, Rutgers University, New Brunswick, NJ 08901, USA 4Division of Endocrinology, Metabolism an...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2021
ISSN: 0903-1936,1399-3003
DOI: 10.1183/13993003.00653-2021